The easiest way to get to Diafani is by ship from the island of Rhodes. There are many Olympic Airways or charter flights to Rhodes. It is also possible to arrive in Diafani by ship from Athens-Piraeus.

There are also some Olympic Airlines flights and some charter flights direct to the small airport in the south of Karpathos. You can then take a taxi over the bumpy mountain road or get the morning Tourist Boat up the coast to Diafani.